inpatient / neurology

Headache and Migraine

Last Updated: 1/8/2023

# Headache

Checklist
-- Chart Check: meds (AC), prior head imaging, h/o cancer, immunosuppression
-- HPI Intake: *onset, timing, location/radiation, quality, severity, triggers, aura, other symptoms, red flags (focal deficit, meningeal signs, fevers, AMS, new >35-50yo, acute and severe, worse with exertion, worse in AM, wakes at night, immunosuppressed, h/o cancer), medications, caffeine
-- Can't Miss: SAH, stroke, meningitis, hypertensive encephalopathy, CNS tumor, temporal arteritis, cerebral venous thrombosis
-- Admission Orders: Labs - CBC, TSH; If red flags - get non-con head CT (thunderclap, trauma, new HA) or brain MRI with contrast (chronic headache but change in severity or pattern)
-- Initial Treatment to Consider: NSAIDs, tylenol, reglan

Intake
-- Onset: ***
-- Timing: ***
duration of episodes, frequency
-- Location/Radiation: ***
-- Quality: ***
band-like vs pulsing
-- Severity: ***
-- Triggers: ***
stress, poor sleep, food, EtOH, menstruation, positional
-- Aura: ***
-- Associated Sxs: ***
pounding, photo/phonophobia, N/V
-- Red Flags: ***
focal neuro exam, meningeal signs, fevers, AMS, new >35-50 yo, acute and severe, worse with exertion, worse when wake up, wakes up at night, immunosuppressed, h/o cancer
-- Medications: ***
analgesics, AC, OCPs
-- Caffeine: ***

Assessment:
-- History: *** timing, triggers, immunosuppressed, h/o cancer
-- Clinical: *** red flags - fevers, AMS, vision change, focal deficits, meningeal signs, worst of life, within minutes
-- Exam: *** focal neuro deficit, meningel signs (nuchal rigidity), tenderness over temporal artery, tenderness over sinuses, dental
-- Data: *** CT Head
-- Etiology/DDx: *** Common - tension, migraine, med overuse; Can’t Miss - meningitis, HTN emergency, SAH, stroke, cerebral sinus thrombosis, tumor; Other - trigeminal neuralgia, cervicogenic

The patient's HPI is notable for ***. Exam showed ***. Labwork and data were notable for ***. Taken together, the patient's presentation is most concerning for ***, with a differential including ***.

Plan:
Workup
-- Imaging: *** if any red flags - focal neuro exam, meningeal signs, fevers, AMS, new >35-50 yo, acute and severe, worse with exertion, worse when waking up, wakes up at night, immunosuppressed, h/o cancer)

Treatment
-- Abortives: *** ibuprofen 400-600mg, tylenol 1000mg, excedrin; sumatriptan 50-100mg; not to be used more than 2-3 times per week or 10 times per month
-- Preventatives: *** amitriptyline 10-50mg, venlafaxine 37.5-150mg, topiramate 25-100mg
-- Supplements: *** Magnesium 400mg-800 BID, riboflavin 400mg, Coenzyme Q10 100mg TID
-- Triggers: avoid known triggers including ***

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If You Remember Nothing Else

Headaches are common and rarely indicate a life-threatening etiology. Red flags include focal neuro exam, meningeal signs, fevers, AMS, new >35-50 yo, acute and severe, worse with exertion, worse when wake up, wakes up at night, immunosuppressed, h/o cancer. Inpatient pain management is with tylenol, NSAIDs, and other abortants like reglan. Abortives like excedrin and triptans should not be used more than 2-3x per week, or 10x per month; they are best used ASAP when symptoms start.

Clinical Pearls

  • Headaches are one of the most common symptoms in daily life, but can also be debilitating and in rare cases life-threatening depending on the underlying etiology
  • "The best predictors [for Migraine] can be summarized by the mnemonic POUNDing (Pulsating, duration of 4-72 hOurs, Unilateral, Nausea, Disabling). If 4 of the 5 criteria are met, the likelihood ratio (LR) for definite or possible migraine is 24; if 3 are met, the LR is 3.5, and if 2 or fewer are met, the LR is 0.41"  (JAMA, 2006)
  • "On physical examination, the absence of fever, neck stiffness, and altered mental status effectively eliminates meningitis (sensitivity, 99%-100% for the presence of 1 of these findings)" (JAMA, 1999)
  • Supplements that may help with migraine include Magnesium 400mg daily up to 800 BID (SE's diarrhea), Riboflavin (B2) 400mg daily, Coenzyme Q10 100mg TID; these are often worth trying in the outpatient setting since there are few if any side effects and they are cheap

Trials and Literature

  • Does This Patient With Headache have a Migraine or Need Neuroimaging? (JAMA, 2006)
  • Does This Adult Patient Have Acute Meningitis? (JAMA, 1999)

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